PD-1 Status in CD8+ T Cells Associates with Survival and …
In peripheral blood, we observed that PD-1 is mainly expressed on effector T cells rather than by naïve T-cell populations. Despite an overall higher PD-1 + CD8 + T-cell frequency in the TIL of HPV + HNC patients, HPV − patients had larger fractions of PD-1 high
PD-1–Mediated Attrition of Polyfunctional Memory CD8+ …
· Although PD-1 expression on memory CD8 + T cells did not have a 1 to 1 correlation with levels of IFN-γ and granzyme B expression, PD-1–expressing memory CD8 + T cells were indeed more apoptotic. Although high levels of active caspase 3 were also noted for polyfunctional effector CD8 + T cells, this subset exhibited minimal PD-1 expression.
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PD-1 up-regulation is correlated with HIV-specific …
The immunoreceptor PD-1 is significantly up-regulated on exhausted CD8 + T cells during chronic viral infections such as HIV-1. However, it remains unknown whether PD-1 expression on CD8 + T cells differs between typical progressors (TPs) and long-term nonprogressors (LTNPs).
JCI
· CD8 + lymphocytes in the tumor display distinct phenotypic traits with increased but variable expression of PD-1, LAG-3, TIM-3, and 4-1BB. To investigate whether the state of differentiation of CD8 + TILs from freshly excised melanoma lesions or expression of markers characteristic of chronic or acute antigen-specific stimulation could guide the identification of tumor-reactive cells, we
Proliferative CD8(+) PD-1(+) T-cell infiltration in a …
Kamphorst AO, Pillai RN, Yang S et al (2017) Proliferation of PD-1+ CD8 T cells in peripheral blood after PD-1-targeted therapy in lung cancer patients. Proc Natl Acad Sci …
Immunoscore system combining CD8 and PD-1/PD-L1: A …
· In melanoma, high expression of PD-1 of CD8 + T cells is associated with the response to PD-1 mAb therapy. 23 In our results, patients with CD8 more PD-1 low had significantly better OS compared with those with CD8 less PD-1 high. This may provide clues +
Dickkopf 1 impairs the tumor response to PD-1 blockade …
To assess the importance of PD-1 in DKK1-mediated T-cell suppression, PD-1 was neutralized during stimulation and DKK1 treatment of CD8+ T cells. In contrast to our hypothesis, we detected a decrease in many activation markers in CD8+ T cells after DKK1 treatment ( figure …
PD-1-expressing B cells suppress CD4+ and CD8+ T …
· PD-1 + and PD-1 − B cells were coincubated with autologous CD4 + and CD8 + T cells at 1: 2 ratio. T cells were stimulated with 2 μg/mL anti-human CD3 and 4 μg/mL anti-human CD28 (BioLegend). In select experiments, 10 μg/mL anti-PD-L1 antibody MIH3 or irrelevant mouse IgG1, κ isotype control (BioLegend) was added.
Circulating mucosal-associated invariant T cells identify …
· Kamphorst, A. O. et al. Proliferation of PD-1+ CD8 T cells in peripheral blood after PD-1-targeted therapy in lung cancer patients. Proc. Natl Acad. Sci. USA 114 , 4993–4998 (2017).
Functional characterization of PD1+TIM3+ tumor …
· CD8 + TILs that upregulate PD1 expression display an exhausted phenotype. 8 PD1 is a surrogate marker of T-cell exhaustion and acts by negatively regulating T-cell receptor (TCR) and CD28 signaling and decreasing proliferation and cytokine secretion of T cells upon engagement with its ligands (PD-L1 and PD-L2). 9,10 Accumulated data indicate that PD1 and PD-L1 are highly expressed in the …
A transcriptionally and functionally distinct PD-1+ …
This CD8(+) T cell population was only found in lymphoid tissues and resided predominantly in the T cell zones along with naive CD8(+) T cells. These PD-1(+)CD8(+) T cells were stem cell-like
Expansion of a CD8+PD-1+ Replicative Senescence …
PD-1 + CD8 + T cells in CLL IR and CLL NR patients and CMV-seropositive and CMV-seronegative patients. PD-1 expression was assessed in CD8 + T cells and was expressed as percentage PD-1–positive cells above isotype control. A, shows that PD-1 is +
Unraveling the Role of Immune Checkpoints in …
· PD-1 CD8 + T cells L. mexicana Humans CD8 + T cells from diffuse form caused by L. mexicana have a lower capacity to proliferate, lower IFN-γ production and enhanced PD-1 expression. (83) CD8 + T cells Lipophosphoglycan vaccination Mice Vaccination of +
Development and validation of a PD-L1/PD-1/CD8 axis …
· The expression status of programmed cell death-ligand 1/programmed cell death 1 (PD-L1/PD-1) and the infiltration of CD8+ T cells in tumor tissues are considered to be related to immunotherapy efficacy and patient prognosis. The purpose of this study is to clarify the prognostic value of the PD-L1/PD-1/CD8 axis, and to develop and validate a comprehensive scoring system based on …